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The Interprofessional Simulation and Innovation Center (ISIC) has a presence on É«ÏãÊÓƵ's Portland and Biddeford campuses. In Portland, it occupies part of the first floor of Innovation Hall, near the classrooms and pre-function space. In Biddeford, the center has dedicated space in the Harold Alfond Forum.

The center offers seven simulation labs with adjoining fully-equipped control rooms, a task training lab, and debriefing classrooms. The program also has dedicated space for professional staff offices, welcoming visitors, and storage. All of the labs are flexible and fully equipped for audiovisual recording, presentations, and debriefing.